fiff_cov.cpp

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//=============================================================================================================
 
//=============================================================================================================
// INCLUDES
//=============================================================================================================
 
#include "fiff_cov.h"
#include "fiff_stream.h"
#include "fiff_raw_data.h"
#include "fiff_evoked_set.h"
#include "fiff_info_base.h"
#include "fiff_dir_node.h"
#include "fiff_file.h"
 
#include <math/linalg.h>
 
//=============================================================================================================
// QT INCLUDES
//=============================================================================================================
 
#include <QPair>
#include <QFile>
 
//=============================================================================================================
// EIGEN INCLUDES
//=============================================================================================================
 
#include <Eigen/SVD>
#include <QDebug>
 
#include <stdexcept>
//=============================================================================================================
// USED NAMESPACES
//=============================================================================================================
 
using namespace FIFFLIB;
using namespace UTILSLIB;
using namespace Eigen;
 
//=============================================================================================================
// DEFINE MEMBER METHODS
//=============================================================================================================
 
FiffCov::FiffCov()
: kind(-1)
, diag(false)
, dim(-1)
, nfree(-1)
{
    qRegisterMetaType<QSharedPointer<FIFFLIB::FiffCov>>("QSharedPointer<FIFFLIB::FiffCov>");
    qRegisterMetaType<FIFFLIB::FiffCov>("FIFFLIB::FiffCov");
}
 
//=============================================================================================================
 
FiffCov::FiffCov(QIODevice& p_IODevice)
: kind(-1)
, diag(false)
, dim(-1)
, nfree(-1)
{
    FiffStream::SPtr t_pStream(new FiffStream(&p_IODevice));
 
    if (!t_pStream->open()) {
        throw std::runtime_error("Not able to open IODevice");
    }
 
    if (!t_pStream->read_cov(t_pStream->dirtree(), FIFFV_MNE_NOISE_COV, *this))
        throw std::runtime_error("Fiff covariance not found");
 
    qRegisterMetaType<QSharedPointer<FIFFLIB::FiffCov>>("QSharedPointer<FIFFLIB::FiffCov>");
    qRegisterMetaType<FIFFLIB::FiffCov>("FIFFLIB::FiffCov");
}
 
//=============================================================================================================
 
FiffCov::FiffCov(const FiffCov& p_FiffCov)
: QSharedData(p_FiffCov)
, kind(p_FiffCov.kind)
, diag(p_FiffCov.diag)
, dim(p_FiffCov.dim)
, names(p_FiffCov.names)
, data(p_FiffCov.data)
, projs(p_FiffCov.projs)
, bads(p_FiffCov.bads)
, nfree(p_FiffCov.nfree)
, eig(p_FiffCov.eig)
, eigvec(p_FiffCov.eigvec)
{
    qRegisterMetaType<QSharedPointer<FIFFLIB::FiffCov>>("QSharedPointer<FIFFLIB::FiffCov>");
    qRegisterMetaType<FIFFLIB::FiffCov>("FIFFLIB::FiffCov");
}
 
//=============================================================================================================
 
FiffCov::~FiffCov()
{
}
 
//=============================================================================================================
 
void FiffCov::clear()
{
    kind = -1;
    diag = false;
    dim = -1;
    names.clear();
    data = MatrixXd();
    projs.clear();
    bads.clear();
    nfree = -1;
    eig = VectorXd();
    eigvec = MatrixXd();
}
 
//=============================================================================================================
 
FiffCov FiffCov::pick_channels(const QStringList& p_include, const QStringList& p_exclude)
{
    RowVectorXi sel = FiffInfoBase::pick_channels(this->names, p_include, p_exclude);
    FiffCov res; //No deep copy here - since almost everything else is adapted anyway
 
    res.kind = this->kind;
    res.diag = this->diag;
    res.dim = sel.size();
 
    for (qint32 k = 0; k < sel.size(); ++k)
        res.names << this->names[sel(k)];
 
    res.data.resize(res.dim, res.dim);
    for (qint32 i = 0; i < res.dim; ++i)
        for (qint32 j = 0; j < res.dim; ++j)
            res.data(i, j) = this->data(sel(i), sel(j));
    res.projs = this->projs;
 
    for (qint32 k = 0; k < this->bads.size(); ++k)
        if (res.names.contains(this->bads[k]))
            res.bads << this->bads[k];
    res.nfree = this->nfree;
 
    return res;
}
 
//=============================================================================================================
 
FiffCov FiffCov::prepare_noise_cov(const FiffInfo& p_Info, const QStringList& p_ChNames) const
{
    FiffCov p_NoiseCov(*this);
 
    VectorXi C_ch_idx = VectorXi::Zero(p_NoiseCov.names.size());
    qint32 count = 0;
    for (qint32 i = 0; i < p_ChNames.size(); ++i) {
        qint32 idx = p_NoiseCov.names.indexOf(p_ChNames[i]);
        if (idx > -1) {
            C_ch_idx[count] = idx;
            ++count;
        }
    }
    C_ch_idx.conservativeResize(count);
 
    MatrixXd C(count, count);
 
    if (!p_NoiseCov.diag)
        for (qint32 i = 0; i < count; ++i)
            for (qint32 j = 0; j < count; ++j)
                C(i, j) = p_NoiseCov.data(C_ch_idx(i), C_ch_idx(j));
    else {
        qWarning("Warning in FiffCov::prepare_noise_cov: This has to be debugged - not done before!");
        C = MatrixXd::Zero(count, count);
        for (qint32 i = 0; i < count; ++i)
            C.diagonal()[i] = p_NoiseCov.data(C_ch_idx(i), 0);
    }
 
    MatrixXd proj;
    qint32 ncomp = p_Info.make_projector(proj, p_ChNames);
 
    //Create the projection operator
    if (ncomp > 0 && proj.rows() == count) {
        qInfo("Created an SSP operator (subspace dimension = %d)\n", ncomp);
        C = proj * (C * proj.transpose());
    } else {
        qWarning("Warning in FiffCov::prepare_noise_cov: No projections applied since no projectors specified or projector dimensions do not match!");
    }
 
    RowVectorXi pick_meg = p_Info.pick_types(true, false, false, defaultQStringList, p_Info.bads);
    RowVectorXi pick_eeg = p_Info.pick_types(false, true, false, defaultQStringList, p_Info.bads);
 
    QStringList meg_names, eeg_names;
 
    for (qint32 i = 0; i < pick_meg.size(); ++i)
        meg_names << p_Info.chs[pick_meg[i]].ch_name;
    VectorXi C_meg_idx = VectorXi::Zero(p_NoiseCov.names.size());
    count = 0;
    for (qint32 k = 0; k < C.rows(); ++k) {
        if (meg_names.indexOf(p_ChNames[k]) > -1) {
            C_meg_idx[count] = k;
            ++count;
        }
    }
    if (count > 0)
        C_meg_idx.conservativeResize(count);
    else
        C_meg_idx = VectorXi();
 
    //
    for (qint32 i = 0; i < pick_eeg.size(); ++i)
        eeg_names << p_Info.chs[pick_eeg(0, i)].ch_name;
    VectorXi C_eeg_idx = VectorXi::Zero(p_NoiseCov.names.size());
    count = 0;
    for (qint32 k = 0; k < C.rows(); ++k) {
        if (eeg_names.indexOf(p_ChNames[k]) > -1) {
            C_eeg_idx[count] = k;
            ++count;
        }
    }
 
    if (count > 0)
        C_eeg_idx.conservativeResize(count);
    else
        C_eeg_idx = VectorXi();
 
    bool has_meg = C_meg_idx.size() > 0;
    bool has_eeg = C_eeg_idx.size() > 0;
 
    MatrixXd C_meg, C_eeg;
    VectorXd C_meg_eig, C_eeg_eig;
    MatrixXd C_meg_eigvec, C_eeg_eigvec;
    if (has_meg) {
        count = C_meg_idx.rows();
        C_meg = MatrixXd(count, count);
        for (qint32 i = 0; i < count; ++i)
            for (qint32 j = 0; j < count; ++j)
                C_meg(i, j) = C(C_meg_idx(i), C_meg_idx(j));
        Linalg::get_whitener(C_meg, false, QString("MEG"), C_meg_eig, C_meg_eigvec);
    }
 
    if (has_eeg) {
        count = C_eeg_idx.rows();
        C_eeg = MatrixXd(count, count);
        for (qint32 i = 0; i < count; ++i)
            for (qint32 j = 0; j < count; ++j)
                C_eeg(i, j) = C(C_eeg_idx(i), C_eeg_idx(j));
        Linalg::get_whitener(C_eeg, false, QString("EEG"), C_eeg_eig, C_eeg_eigvec);
    }
 
    qint32 n_chan = p_ChNames.size();
    p_NoiseCov.eigvec = MatrixXd::Zero(n_chan, n_chan);
    p_NoiseCov.eig = VectorXd::Zero(n_chan);
 
    if (has_meg) {
        for (qint32 i = 0; i < C_meg_idx.rows(); ++i)
            for (qint32 j = 0; j < C_meg_idx.rows(); ++j)
                p_NoiseCov.eigvec(C_meg_idx[i], C_meg_idx[j]) = C_meg_eigvec(i, j);
        for (qint32 i = 0; i < C_meg_idx.rows(); ++i)
            p_NoiseCov.eig(C_meg_idx[i]) = C_meg_eig[i];
    }
    if (has_eeg) {
        for (qint32 i = 0; i < C_eeg_idx.rows(); ++i)
            for (qint32 j = 0; j < C_eeg_idx.rows(); ++j)
                p_NoiseCov.eigvec(C_eeg_idx[i], C_eeg_idx[j]) = C_eeg_eigvec(i, j);
        for (qint32 i = 0; i < C_eeg_idx.rows(); ++i)
            p_NoiseCov.eig(C_eeg_idx[i]) = C_eeg_eig[i];
    }
 
    if (C_meg_idx.size() + C_eeg_idx.size() != n_chan) {
        qWarning("FiffCov::prepare_noise_cov: %lld MEG + %lld EEG channels != %d total (unclassified channels present)",
                 (long long)C_meg_idx.size(), (long long)C_eeg_idx.size(), n_chan);
    }
 
    p_NoiseCov.data = C;
    p_NoiseCov.dim = p_ChNames.size();
    p_NoiseCov.diag = false;
    p_NoiseCov.names = p_ChNames;
 
    return p_NoiseCov;
}
 
//=============================================================================================================
 
FiffCov FiffCov::regularize(const FiffInfo& p_info, double p_fRegMag, double p_fRegGrad, double p_fRegEeg, bool p_bProj, QStringList p_exclude) const
{
    FiffCov cov(*this);
 
    if (p_exclude.size() == 0) {
        p_exclude = p_info.bads;
        for (qint32 i = 0; i < cov.bads.size(); ++i)
            if (!p_exclude.contains(cov.bads[i]))
                p_exclude << cov.bads[i];
    }
 
    //Allways exclude all STI channels from covariance computation
    for (int i = 0; i < p_info.chs.size(); i++) {
        if (p_info.chs[i].kind == FIFFV_STIM_CH) {
            p_exclude << p_info.chs[i].ch_name;
        }
    }
 
    RowVectorXi sel_eeg = p_info.pick_types(false, true, false, defaultQStringList, p_exclude);
    RowVectorXi sel_mag = p_info.pick_types(QString("mag"), false, false, defaultQStringList, p_exclude);
    RowVectorXi sel_grad = p_info.pick_types(QString("grad"), false, false, defaultQStringList, p_exclude);
 
    QStringList info_ch_names = p_info.ch_names;
    QStringList ch_names_eeg, ch_names_mag, ch_names_grad;
    for (qint32 i = 0; i < sel_eeg.size(); ++i)
        ch_names_eeg << info_ch_names[sel_eeg(i)];
    for (qint32 i = 0; i < sel_mag.size(); ++i)
        ch_names_mag << info_ch_names[sel_mag(i)];
    for (qint32 i = 0; i < sel_grad.size(); ++i)
        ch_names_grad << info_ch_names[sel_grad(i)];
 
    // This actually removes bad channels from the cov, which is not backward
    // compatible, so let's leave all channels in
    FiffCov cov_good = cov.pick_channels(info_ch_names, p_exclude);
    QStringList ch_names = cov_good.names;
 
    std::vector<qint32> idx_eeg, idx_mag, idx_grad;
    for (qint32 i = 0; i < ch_names.size(); ++i) {
        if (ch_names_eeg.contains(ch_names[i]))
            idx_eeg.push_back(i);
        else if (ch_names_mag.contains(ch_names[i]))
            idx_mag.push_back(i);
        else if (ch_names_grad.contains(ch_names[i]))
            idx_grad.push_back(i);
    }
 
    MatrixXd C(cov_good.data);
 
    //Check dimension consistency (channels not classified as EEG/MAG/GRAD, e.g. EOG/MISC, are expected)
    if (static_cast<unsigned>(C.rows()) != idx_eeg.size() + idx_mag.size() + idx_grad.size()) {
        qWarning("FiffCov::regularize: %lld channels in cov but only %zu classified as EEG/MAG/GRAD (others will not be regularized)",
                 static_cast<long long>(C.rows()), idx_eeg.size() + idx_mag.size() + idx_grad.size());
    }
 
    QList<FiffProj> t_listProjs;
    if (p_bProj) {
        t_listProjs = p_info.projs + cov_good.projs;
        FiffProj::activate_projs(t_listProjs);
    }
 
    //Build regularization MAP
    QMap<QString, QPair<double, std::vector<qint32>>> regData;
    regData.insert("EEG", QPair<double, std::vector<qint32>>(p_fRegEeg, idx_eeg));
    regData.insert("MAG", QPair<double, std::vector<qint32>>(p_fRegMag, idx_mag));
    regData.insert("GRAD", QPair<double, std::vector<qint32>>(p_fRegGrad, idx_grad));
 
    //
    //Regularize
    //
    QMap<QString, QPair<double, std::vector<qint32>>>::Iterator it;
    for (it = regData.begin(); it != regData.end(); ++it) {
        QString desc(it.key());
        double reg = it.value().first;
        std::vector<qint32> idx = it.value().second;
 
        if (idx.size() == 0 || reg == 0.0)
            qInfo("\tNothing to regularize within %s data.\n", desc.toUtf8().constData());
        else {
            qInfo("\tRegularize %s: %f\n", desc.toUtf8().constData(), reg);
            MatrixXd this_C(idx.size(), idx.size());
            for (quint32 i = 0; i < idx.size(); ++i)
                for (quint32 j = 0; j < idx.size(); ++j)
                    this_C(i, j) = cov_good.data(idx[i], idx[j]);
 
            MatrixXd U;
            // Only assigned when projecting, but read again below to decide
            // whether the SSP operator has to be undone. Without projection
            // there are no components to remove.
            qint32 ncomp = 0;
            if (p_bProj) {
                QStringList this_ch_names;
                for (quint32 k = 0; k < idx.size(); ++k)
                    this_ch_names << ch_names[idx[k]];
 
                MatrixXd P;
                ncomp = FiffProj::make_projector(t_listProjs, this_ch_names, P); //ToDo: Synchronize with mne-python and debug
 
                JacobiSVD<MatrixXd> svd(P, ComputeFullU);
                //Sort singular values and singular vectors
                VectorXd t_s = svd.singularValues();
                MatrixXd t_U = svd.matrixU();
                Linalg::sort<double>(t_s, t_U);
 
                U = t_U.block(0, 0, t_U.rows(), t_U.cols() - ncomp);
 
                if (ncomp > 0) {
                    qInfo("\tCreated an SSP operator for %s (dimension = %d).\n", desc.toUtf8().constData(), ncomp);
                    this_C = U.transpose() * (this_C * U);
                }
            }
 
            double sigma = this_C.diagonal().mean();
            this_C.diagonal() = this_C.diagonal().array() + reg * sigma; // modify diag inplace
            if (p_bProj && ncomp > 0)
                this_C = U * (this_C * U.transpose());
 
            for (qint32 i = 0; i < this_C.rows(); ++i)
                for (qint32 j = 0; j < this_C.cols(); ++j)
                    C(idx[i], idx[j]) = this_C(i, j);
        }
    }
 
    // Put data back in correct locations
    RowVectorXi idx = FiffInfo::pick_channels(cov.names, info_ch_names, p_exclude);
    for (qint32 i = 0; i < idx.size(); ++i)
        for (qint32 j = 0; j < idx.size(); ++j)
            cov.data(idx[i], idx[j]) = C(i, j);
 
    return cov;
}
 
//=============================================================================================================
 
FiffCov& FiffCov::operator=(const FiffCov& rhs)
{
    if (this != &rhs) // protect against invalid self-assignment
    {
        kind = rhs.kind;
        diag = rhs.diag;
        dim = rhs.dim;
        names = rhs.names;
        data = rhs.data;
        projs = rhs.projs;
        bads = rhs.bads;
        nfree = rhs.nfree;
        eig = rhs.eig;
        eigvec = rhs.eigvec;
    }
    // to support chained assignment operators (a=b=c), always return *this
    return *this;
}
 
//=============================================================================================================
 
FiffCov FiffCov::compute_from_epochs(const FiffRawData& raw,
                                     const MatrixXi& events,
                                     const QList<int>& eventCodes,
                                     float tmin,
                                     float tmax,
                                     float bmin,
                                     float bmax,
                                     bool doBaseline,
                                     bool removeMean,
                                     unsigned int ignoreMask,
                                     float delay,
                                     const RejectionParams* rej)
{
    FiffCov cov;
    float sfreq = raw.info.sfreq;
    int nchan = raw.info.nchan;
 
    int minSamp = static_cast<int>(std::round(tmin * sfreq));
    int maxSamp = static_cast<int>(std::round(tmax * sfreq));
    int ns = maxSamp - minSamp + 1;
    int delaySamp = static_cast<int>(std::round(delay * sfreq));
 
    if (ns <= 0) {
        qWarning() << "[FiffCov::compute_from_epochs] Invalid time window.";
        return cov;
    }
 
    int bminSamp = 0, bmaxSamp = 0;
    if (doBaseline) {
        bminSamp = static_cast<int>(std::round(bmin * sfreq)) - minSamp;
        bmaxSamp = static_cast<int>(std::round(bmax * sfreq)) - minSamp;
    }
 
    MatrixXd covAccum = MatrixXd::Zero(nchan, nchan);
    VectorXd meanAccum = VectorXd::Zero(nchan);
    int totalSamples = 0;
    int nAccepted = 0;
 
    for (int k = 0; k < events.rows(); ++k) {
        int evFrom = events(k, 1) & ~static_cast<int>(ignoreMask);
        int evTo = events(k, 2) & ~static_cast<int>(ignoreMask);
 
        // Check if event matches any of the desired event codes
        bool match = false;
        for (int ec = 0; ec < eventCodes.size(); ++ec) {
            if (evFrom == 0 && evTo == eventCodes[ec]) {
                match = true;
                break;
            }
        }
        if (!match)
            continue;
 
        int evSample = events(k, 0);
        int epochStart = evSample + delaySamp + minSamp;
        int epochEnd = evSample + delaySamp + maxSamp;
 
        if (epochStart < raw.first_samp || epochEnd > raw.last_samp)
            continue;
 
        MatrixXd epochData;
        MatrixXd epochTimes;
        if (!raw.read_raw_segment(epochData, epochTimes, epochStart, epochEnd))
            continue;
        QString reason;
        if (rej && !FiffEvokedSet::checkArtifacts(epochData, raw.info, raw.info.bads, *rej, reason)) {
            qInfo().noquote() << "[FiffCov::compute_from_epochs] Rejected epoch at" << evSample << reason;
            continue;
        }
 
        // Baseline subtraction
        if (doBaseline) {
            int bminIdx = qMax(0, bminSamp);
            int bmaxIdx = qMin(static_cast<int>(epochData.cols()) - 1, bmaxSamp);
            if (bmaxIdx >= bminIdx) {
                int nBase = bmaxIdx - bminIdx + 1;
                for (int c = 0; c < nchan; ++c) {
                    double baseVal = epochData.row(c).segment(bminIdx, nBase).mean();
                    epochData.row(c).array() -= baseVal;
                }
            }
        }
 
        // Accumulate
        if (removeMean) {
            VectorXd epochMean = epochData.rowwise().mean();
            meanAccum += epochMean * static_cast<double>(ns);
        }
        covAccum += epochData * epochData.transpose();
        totalSamples += ns;
        nAccepted++;
    }
 
    if (totalSamples < 2) {
        qWarning() << "[FiffCov::compute_from_epochs] Not enough data.";
        return cov;
    }
 
    if (removeMean) {
        VectorXd grandMean = meanAccum / static_cast<double>(totalSamples);
        cov.data = (covAccum / static_cast<double>(totalSamples - 1)) - (grandMean * grandMean.transpose()) * (static_cast<double>(totalSamples) / (totalSamples - 1));
    } else {
        cov.data = covAccum / static_cast<double>(totalSamples - 1);
    }
 
    cov.kind = FIFFV_MNE_NOISE_COV;
    cov.dim = nchan;
    cov.names = raw.info.ch_names;
    cov.nfree = totalSamples - 1;
    cov.bads = raw.info.bads;
    cov.projs = raw.info.projs;
 
    qInfo() << "[FiffCov::compute_from_epochs] Computed:" << nchan << "channels,"
            << nAccepted << "epochs," << totalSamples << "total samples.";
 
    return cov;
}
 
//=============================================================================================================
 
bool FiffCov::save(const QString& fileName) const
{
    if (fileName.isEmpty()) {
        qWarning() << "[FiffCov::save] Output file not specified.";
        return false;
    }
 
    QFile file(fileName);
    FiffStream::SPtr pStream = FiffStream::start_file(file);
    if (!pStream) {
        qWarning() << "[FiffCov::save] Cannot open" << fileName;
        return false;
    }
 
    pStream->start_block(FIFFB_MEAS);
    pStream->write_id(FIFF_BLOCK_ID);
    pStream->write_cov(*this);
    pStream->end_block(FIFFB_MEAS);
    pStream->end_file();
 
    qInfo() << "[FiffCov::save] Saved covariance matrix to" << fileName;
    return true;
}
 
//=============================================================================================================
 
FiffCov FiffCov::computeGrandAverage(const QList<FiffCov>& covs)
{
    FiffCov grandCov;
 
    if (covs.isEmpty()) {
        qWarning() << "[FiffCov::computeGrandAverage] No covariance matrices provided.";
        return grandCov;
    }
 
    grandCov = covs[0];
    MatrixXd sumCov = grandCov.data * static_cast<double>(grandCov.nfree);
    int totalNfree = grandCov.nfree;
 
    for (int k = 1; k < covs.size(); ++k) {
        if (covs[k].dim != grandCov.dim) {
            qWarning() << "[FiffCov::computeGrandAverage] Dimension mismatch.";
            return FiffCov();
        }
        sumCov += covs[k].data * static_cast<double>(covs[k].nfree);
        totalNfree += covs[k].nfree;
    }
 
    grandCov.data = sumCov / static_cast<double>(totalNfree);
    grandCov.nfree = totalNfree;
 
    return grandCov;
}